Publications

2020
Danielle Klinger, Blass, Ido , Rappoport, Nadav , and Linial, Michal . 2020. “Significantly Improved Covid-19 Outcomes In Countries With Higher Bcg Vaccination Coverage: A Multivariable Analysis”. Vaccines.
Kerem Wainer-Katsir and Linial, Michal . 2020. “Bird: Identifying Cell Doublets Via Biallelic Expression From Single Cells”. Bioinformatics, Pp. 709451.
Nadav Brandes, Linial, Nathan , and Linial, Michal . 2020. “Functional Evolutionary Modeling Exposes Overlooked Protein-Coding Genes Involved In Cancer”. International Symposium On Bioinformatics Research And Applications.
Nadav Brandes, Linial, Nathan , and Linial, Michal . 2020. “Pwas: Proteome-Wide Association Study&Mdash;Linking Genes And Phenotypes By Functional Variation In Proteins”. Genome Biology.
Ehud Banne, Falik-Zaccai, Tzipora , Brielle, Esther , Kalfon, Limor , Ladany, Hagay , Klinger, Danielle , Schneidman-Duhovny, Dina , and Linial, Michal . 2020. “Structural Analysis Of De Novo Stxbp1 Mutation In Complex With Syntaxin 1A Reveals A Major Alteration In The Interaction Interface In A Child With Developmental Delay And Spasticity”. Neuropsychiatric Genetics, Pp. 642702.
2019
Naihui Zhou, Jiang, Yuxiang , Bergquist, Timothy R, Lee, Alexandra J, Kacsoh, Balint Z, Crocker, Alex W, Lewis, Kimberley A, Georghiou, George , Nguyen, Huy N, Hamid, Md Nafiz , and others, . 2019. “The Cafa Challenge Reports Improved Protein Function Prediction And New Functional Annotations For Hundreds Of Genes Through Experimental Screens”. Biorxiv, Pp. 653105.
Larysa Poluben, Puligandla, Maneka , Neuberg, Donna , Bryke, Christine R, Hsu, Yahsuan , Shumeiko, Oleksandr , Yuan, Xin , Voznesensky, Olga , Pihan, German , Adam, Miriam , and others, . 2019. “Characteristics Of Myeloproliferative Neoplasms In Patients Exposed To Ionizing Radiation Following The Chernobyl Nuclear Accident”. American Journal Of Hematology, 94, 1, Pp. 62–73.
Kerem Wainer Katsir and Linial, Michal . 2019. “Human Genes Escaping X-Inactivation Revealed By Single Cell Expression Data”. Bmc Genomics, 20, 1, Pp. 201.
Nadav Brandes, Linial, Nathan , and Linial, Michal . 2019. “Quantifying Gene Selection In Cancer Through Protein Functional Alteration Bias”. Nucleic Acids Research.
Nadav Brandes and Linial, Michal . 2019. “Giant Viruses&Mdash;Big Surprises”. Viruses, 11, 5, Pp. 404.
Viruses
2018
Shai Shoham, Linial, Michal , and Weinstock, Marta . 2018. “Age-Induced Spatial Memory Deficits In Rats Are Correlated With Specific Brain Region Alterations In Microglial Morphology And Gene Expression.”. J Neuroimmune Pharmacol. doi:10.1007/s11481-018-9817-2. Abstract
Effect of age and ladostigil treatment (1 mg/kg/day), given for 6 months to 16 month old rats, was investigated on microglial morphology in brain regions associated with control of spatial learning. This was assessed in the Morris water maze (MWM). Microglial morphology was assessed with diaminobenzidine and fluorescent staining with Iba1 and CD11b in these brain regions. Aging did not change the number of microglia in the parietal cortex (PC) or hippocampal CA1 region (CA1-HC), but decreased microglial process tips in the CA1-HC, increased the area fraction stained by CD11b and number of bulbs on processes in PC and CA1-HC and thickness of microglial processes in corpus callosum (CC) and fornix (Fx). Performance in MWM (distance swam to escape platform) was negatively correlated with number of bulbs in PC and thickness of process in CC, and positively correlated with number of process tips in CA1-HC. Aging increased expression of MHC class II genes and others associated with motility and membrane adhesion in the PC and hippocampus, but Adora2a (Adenosine A2a receptor), only in hippocampus. Age-related increase in the number of bulbs and expression of inflammatory genes was prevented by ladostigil in PC. In the CA1-HC, ladostigil increased the number of process tips and prevented the increase in expression of Adora2a and genes regulating ion channels. Ladostigil also decreased thickening of the processes in CC and Fx. The data show brain region-specific relations induced by age in spatial learning, microglial morphology and associated genes and their response to ladostigil treatment. Graphical Abstract.
Shelly Mahlab-Aviv, Linial, Nathan , and Linial, Michal . 2018. “A Cell-Based Probabilistic Approach Unveils The Concerted Action Of Mirnas”. Biorxiv, Pp. 298596.
Nadav Brandes, Linial, Nathan , and Linial, Michal . 2018. “Modeling Functional Genetic Alteration In Cancer Reveals New Candidate Driver Genes”. Biorxiv, Pp. 242354.
Shelly Mahlab-Aviv, Boulos, Ayub , Peretz, Ayelet R, Eliyahu, Tsiona , Carmel, Liran , Sperling, Ruth , and Linial, Michal . 2018. “Small Rna Sequences Derived From Pre-Micrornas In The Supraspliceosome”. Nucleic Acids Research, 46, 20, Pp. 11014–11029.
Roni Rasnic, Brandes, Nadav , Zuk, Or , and Linial, Michal . 2018. “Substantial Batch Effects In Tcga Exome Sequences Undermine Pan-Cancer Analysis Of Germline Variants”. Biorxiv, Pp. 445049.
Shelly Mahlab-Aviv, Linial, Nathan , and Linial, Michal . 2018. “The Translation Machinery Is Immune From Mirna Perturbations: A Cell-Based Probabilistic Approach”. Biorxiv, Pp. 298596.
2017
Roni Rasnic, Linial, Nathan , and Linial, Michal . 2017. “Enhancing Identification Of Cancer Types Via Lowly-Expressed Micrornas”. Nucleic Acids Research, 45, 9, Pp. 5048–5060.
Michal Linial, Rappoport, Nadav , and Ofer, Dan . 2017. “Overlooked Short Toxin-Like Proteins: A Shortcut To Drug Design”. Toxins, 9, 11, Pp. 350.
S Mahlab-Aviv, Peretz, A, Carmel, L, Sperling, R, and Linial, M. 2017. “A Selected Set Of Mature Micrornas Is Associated With The Endogenous Spliceosome”. In Febs Journal, 284:Pp. 172–172. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.

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